This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …

Several chronic infections known to be associated with malignancy have established
oncogenic properties. However the existence of chronic inflammatory conditions that do not …

Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …

Purpose Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against
colorectal cancer (CRC) and are associated with reduced disease recurrence and improved …

In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of
phospholipase A2 and the release of arachidonic acid from membrane phospholipids in …

Background & Aims: The endocannabinoids anandamide and 2-arachidonoylglycerol (2-
AG) inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied …

Background: Experimental studies indicate the chemopreventive properties of green tea
extract (GTE) on colorectal cancer. Epidemiologically, green tea consumption of> 10 cups …

Cancer-induced angiogenesis is the result of increased expression of angiogenic factors, or
decreased expression of anti-angiogenic factors, or a combination of both events. For …

PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including
colorectal cancer (CRC). Mutations of PIK3CA have been reported in 10–20% of CRC …