The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells
can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate …

Abstract The α9-and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate
numerous physiological and pathological processes by complex mechanisms that are …

Due to the microenvironment created by Schwann cell (SC) activity, peripheral nerve fibers
are able to regenerate. Inflammation is the first response to nerve damage and the removal …

This work deals with development of polyfunctional biocompatible cationic surfactant
systems based on bioactive saturated bicyclic alkaloid quinuclidine. It is focused on the …

Several lines of evidence have indicated that nicotinic acetylcholine receptors (nAChR) that
contain α9 subunits, probably in combination with α10 subunits, may be valuable targets for …

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor
desensitization and promote the α7 metabotropic function, are emerging as new promising …

A lack of selectivity of classical agonists for the nicotinic acetylcholine receptors (nAChR)
has prompted us to identify and develop a distinct scaffold of α7 nAChR-selective ligands …

Purpose The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation
of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of …