L-carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine

MR McCann, MV George De la Rosa, GR Rosania… - Metabolites, 2021 - mdpi.com
Biomarker discovery and implementation are at the forefront of the precision medicine
movement. Modern advances in the field of metabolomics afford the opportunity to readily …

Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

RJ Reiter, S Rosales-Corral, DX Tan, MJ Jou… - Cellular and molecular …, 2017 - Springer
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

BTS guideline for oxygen use in adults in healthcare and emergency settings

BR O'Driscoll, LS Howard, J Earis, V Mak - Thorax, 2017 - thorax.bmj.com
BTS guideline for oxygen use in adults in healthcare and emergency settings | Thorax Skip to
main content Viewing from: Google Indexer BMJ Journals Subscribe Log In More Log in via …

A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury

H Gomez, C Ince, D De Backer, P Pickkers, D Payen… - Shock, 2014 - journals.lww.com
Given that the leading clinical conditions associated with acute kidney injury (AKI), namely,
sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is …

Oxidative stress and mitochondrial dysfunction in sepsis

HF Galley - British journal of anaesthesia, 2011 - academic.oup.com
Sepsis-related organ dysfunction remains the most common cause of death in the intensive
care unit (ICU), despite advances in healthcare and science. Marked oxidative stress as a …

Metabolic alterations in sepsis

W Wasyluk, A Zwolak - Journal of clinical medicine, 2021 - mdpi.com
Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host
response to infection”. Contrary to the older definitions, the current one not only focuses on …

BTS guideline for emergency oxygen use in adult patients

BR O'driscoll, LS Howard, AG Davison - Thorax, 2008 - thorax.bmj.com
EXECUTIVE SUMMARY OF THE GUIDELINE Philosophy of the guideline c Oxygen is a
treatment for hypoxaemia, not breathlessness.(Oxygen has not been shown to have any …

Mitochondria in health and disease: perspectives on a new mitochondrial biology

MR Duchen - Molecular aspects of medicine, 2004 - Elsevier
The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Molecular nephrology: types of acute tubular injury

B Desanti De Oliveira, K Xu, TH Shen… - Nature Reviews …, 2019 - nature.com
The acute loss of kidney function has been diagnosed for many decades using the serum
concentration of creatinine—a muscle metabolite that is an insensitive and non-specific …

[HTML][HTML] The role of mitochondria in sepsis-induced cardiomyopathy

G Stanzani, MR Duchen, M Singer - … Acta (BBA)-Molecular Basis of Disease, 2019 - Elsevier
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. Myocardial dysfunction, often termed sepsis-induced cardiomyopathy …