Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …

Malignant cells exhibit metabolic changes, when compared to their normal counterparts,
owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has …

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical
evidence has linked cell metabolism with cancer outcomes. Together, these observations …

Tumor cells rewire metabolic pathways to adapt to their increased nutritional demands for
energy, reducing equivalents, and cellular biosynthesis. Alternations in amino acid …

Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

Background Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC
often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG …

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. Its
relationship to chronic liver diseases, in particular cirrhosis, develops on a background of …

Highlights•Reviewed the function of arginine and its metabolites in arginine deprivation
therapy.•Discussed the difference of arginine deiminase and recombinant human arginase …

Importance Preclinical studies show that arginine deprivation is synthetically lethal in
argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma. The role …