Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Human cancers are characterized by the presence of oncogene-induced DNA replication
stress (DRS), making them dependent on repair pathways such as break-induced …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

Repair of chromosomal breaks is essential for cellular viability, but misrepair generates
mutations and gross chromosomal rearrangements. We investigated the interrelationship …

Efficient precision genome engineering requires high frequency and specificity of integration
at the genomic target site. Here, we describe a set of resources to streamline reporter gene …