Astrocytes, a class of morphologically and functionally diverse primary homeostatic
neuroglia, are key keepers of neural tissue homeostasis and fundamental contributors to …

Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …

Phospho-tau accumulation and adult hippocampal neurogenesis (AHN) impairment both
contribute importantly to the cognitive decline in Alzheimer's disease (AD), but whether and …

Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This
phenomenon takes place in more than 120 mammalian species, including humans, yet its …

Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …

Neurogenesis ceases in most regions of the mammalian brain before or shortly after birth,
however, in a few restricted brain regions, the production of new neurons proceeds into …

Increased neural stem cell (NSC) quiescence is a major determinant of age-related
regenerative decline in the adult hippocampus. However, a coextensive model has been …

The adult neurogenic niche in the hippocampus is maintained through activation of
reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). Here …

The relationships between impaired cortical development and consequent malformations in
neurodevelopmental disorders, as well as the genes implicated in these processes, are not …