The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …

The physiologically hypoxic intervertebral disc and cartilage rely on the hypoxia-inducible
factor (HIF) family of transcription factors to mediate cellular responses to changes in oxygen …

Mitochondria are multifunctional cellular organelles that are major producers of reactive
oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented …

While metabolism was initially thought to play a passive role in cell biology by generating
ATP to meet bioenergetic demands, recent studies have identified critical roles for …

Epithelial ovarian cancer (EOC) is a gynecologic malignancy with a poor prognosis due to
resistance to first-line chemotherapeutic agents. Some cancer cells are primarily dependent …

Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to
proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor …

Oxygen (O2) is essential for cellular metabolism and biochemical reactions. When the
demand for O2 exceeds the supply, hypoxia occurs. Hypoxia-inducible factors (HIFs) are …