Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviours and although strides have been made using …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Background Opioid use disorder (OUD), a serious health burden worldwide, is associated
with lower cognitive function. Recent studies have demonstrated a negative genetic …

BackgroundElucidation of the interaction of biological and psychosocial/environmental
factors on opioid dependence (OD) risk can inform our understanding of the etiology of OD …

Opioid misuse, addiction, and associated overdose deaths remain global public health
crises. Despite the tremendous need for pharmacological treatments, current options are …

Substance use disorders (SUDs) are highly prevalent and associated with excess morbidity,
mortality, and economic costs. Thus, there is considerable interest in the early identification …

Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …