Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
WG Wood, L Li, WE Müller… - Journal of …, 2014 - Wiley Online Library
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …
Prodrugs of phosphonates and phosphates: crossing the membrane barrier
A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …
Rho-kinase: regulation,(dys) function, and inhibition
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
Use of bisphosphonates and risk of postmenopausal breast cancer
G Rennert, M Pinchev, HS Rennert - Journal of Clinical Oncology, 2010 - ascopubs.org
Purpose Bisphosphonates are commonly used for the treatment of osteoporosis and for
prevention and treatment of skeletal lesions due to malignancy. However, the association …
prevention and treatment of skeletal lesions due to malignancy. However, the association …
Use of bisphosphonates and reduced risk of colorectal cancer
G Rennert, M Pinchev, HS Rennert… - Journal of clinical …, 2011 - ascopubs.org
Purpose Bisphosphonates are commonly used for the treatment of osteoporosis and bone
metastases caused by breast cancer and were recently reported to be associated with a …
metastases caused by breast cancer and were recently reported to be associated with a …
[HTML][HTML] The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region
K Nguyen, J Li, R Puthenveetil, X Lin, MM Poe… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate
(HMBPP), are ligands of the internal domain of BTN3A1. Ligand binding in target cells …
(HMBPP), are ligands of the internal domain of BTN3A1. Ligand binding in target cells …
Reduced risk of colorectal cancer with use of oral bisphosphonates: a systematic review and meta-analysis
Purpose The association between oral bisphosphonate (BP) intake and colorectal cancer
(CRC) risk has been investigated in several recent studies with conflicting results. We …
(CRC) risk has been investigated in several recent studies with conflicting results. We …
Structural and biochemical perspectives in plant isoprenoid biosynthesis
The isoprenoid family represents one of the most ancient and widespread classes of
structurally and functionally rich biomolecules known to man. Although these natural …
structurally and functionally rich biomolecules known to man. Although these natural …
Assessment of isoprene as a possible biosignature gas in exoplanets with anoxic atmospheres
The search for possible biosignature gases in habitable exoplanet atmospheres is
accelerating, although actual observations are likely years away. This work adds isoprene …
accelerating, although actual observations are likely years away. This work adds isoprene …
Geranylgeranyl diphosphate synthase: an emerging therapeutic target
Proteins modified post‐translationally by geranylgeranylation have been implicated in
numerous cellular processes related to human disease. In recent years, the study of protein …
numerous cellular processes related to human disease. In recent years, the study of protein …