The management and treatment of bone cancer pain (BCP) remain significant clinical
challenges, imposing substantial economic burdens on patients and society. Extensive …

HDAC11, as a rising star in the histone deacetylase (HDAC) family, has attracted
widespread interest in the biomedical field in recent years specially owing to its high defatty …

HDAC11 is a class IV histone deacylase with no crystal structure reported so far. The
catalytic domain of HDAC11 shares low sequence identity with other HDAC isoforms, which …

AlphaFold is an artificial intelligence approach for predicting the three‐dimensional (3D)
structures of proteins with atomic accuracy. One challenge that limits the use of AlphaFold …

Abstract Classical Zn2+-dependent deac (et) ylases play fundamental regulatory roles in life
and are well characterized in eukaryotes regarding their structures, substrates and …

Multistep synthesis performed on solid support is a powerful means to generate small-
molecule libraries for the discovery of chemical probes to dissect biological mechanisms as …

Abstract The histone deacetylase 6 (HDAC6) is closely related to the pathogenesis of
depression in epigenetic regulation. However, it remains unclear how HDAC6 expression …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a promising target for the
diagnosis and treatment of various diseases, especially neurodegenerative disorders …

Discovery of novel itaconimide-based derivatives as potent HDAC inhibitors for the efficient
treatment of prostate cancer - ScienceDirect Skip to main contentSkip to article Elsevier logo …

BACKGROUND: Chronic pain is a debilitating medical condition that lacks effective
treatments. Increasing evidence suggests that microglia and neuroinflammation underlie …