Exogenous antioxidants—Double‐edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses

J Bouayed, T Bohn - Oxidative medicine and cellular longevity, 2010 - Wiley Online Library
The balance between oxidation and antioxidation is believed to be critical in maintaining
healthy biological systems. Under physiological conditions, the human antioxidative defense …

Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress

LAA Gilliam, DK St. Clair - Antioxidants & redox signaling, 2011 - liebertpub.com
Significance: Fatigue is one of the most common symptoms of cancer and its treatment,
manifested in the clinic through weakness and exercise intolerance. These side effects not …

Rutin and Quercetin Counter Doxorubicin‐Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

OM Ahmed, MH Elkomy, HI Fahim… - Oxidative Medicine …, 2022 - Wiley Online Library
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver
injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were …

Multi-component herbal products in the prevention and treatment of chemotherapy-associated toxicity and side effects: a review on experimental and clinical …

B Fu, N Wang, HY Tan, S Li, F Cheung… - Frontiers in …, 2018 - frontiersin.org
Chemotherapy is nowadays the main treatment of human cancers. Chemotherapeutic
agents target rapidly dividing cancer cells to suppress tumor progression, however, their non …

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

JQ Ma, Z Li, WR Xie, CM Liu, SS Liu - International immunopharmacology, 2015 - Elsevier
Quercetin (QE), a natural flavonoid, has many medical beneficial effects. However, its
protective effects against carbon tetrachloride (CCl 4) induced injury in liver have not been …

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics

Q Liang, Q Zhao, X Hao, J Wang, C Ma, X Xi… - Frontiers in …, 2022 - frontiersin.org
Proteomics and intestinal flora were used to determine the mechanism of immune
modulatory effects of Flammulina velutipes polysaccharide on immunosuppressed mice …

[PDF][PDF] A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties

NS Alrawaiq, A Abdullah - International Journal of PharmTech …, 2014 - researchgate.net
Flavonoids belong to a category of polyphenolic compounds that are produced exclusively
in plants. These compounds are able to bring about various biological and pharmacological …

Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl

G Wang, J Zhang, L Liu, S Sharma, Q Dong - PloS one, 2012 - journals.plos.org
Background The dose-dependent toxicities of doxorubicin (DOX) limit its clinical
applications, particularly in drug-resistant cancers, such as liver cancer. In this study, we …

Quercetin protects rat liver against lead-induced oxidative stress and apoptosis

CM Liu, YL Zheng, J Lu, ZF Zhang, SH Fan… - Environmental …, 2010 - Elsevier
Quercetin, a flavonoid, effectively improved the lead-induced histology changes including
structure damage and leukocyte infiltration in rat liver. The present study was designed to …

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

HZ Ying, YH Liu, B Yu, ZY Wang, JN Zang… - Food and Chemical …, 2013 - Elsevier
Dietary quercetin is highly abundant in edible plants, which possesses a wide range of
pharmacological properties. This study was to investigate hepatoprotective effects of …