Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage,
reperfusion results in a unique form of myocardial damage. Functional alterations occur …

Mitochondrial oxidative damage contributes to a wide range of pathologies, including
cardiovascular disorders and neurodegenerative diseases. Therefore, protecting …

Ischemic heart disease is a significant cause of morbidity and mortality in Western society.
Although interventions, such as thrombolysis and percutaneous coronary intervention, have …

Flavonoids have long been acknowledged for their unique antioxidant properties, and
possess other activities that may be relevant to heart ischemia–reperfusion. They may …

The pathology of cardiovascular disease (CVD) is complex; multiple biological pathways
have been implicated, including, but not limited to, inflammation and oxidative stress …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

Reperfusion of ischemic myocardium is required for tissue survival; however, reperfusion
elicits pathologic consequences. Myocardial reperfusion injury is a multifarious process that …

Myocardial ischemia is a major cause of morbidity and mortality in the world. Although
restoration of blood flow after prolonged ischemia is essential for cardiomyocytes salvation …

A series of brief (a few minutes) ischemia/reperfusion cycles (ischemic preconditioning, IP)
limits myocardial injury produced by a subsequent prolonged period of coronary artery …