Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …

Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and
maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF …

Background: Marfan syndrome (MFS) is associated with TGF (transforming growth factor) β–
stimulated ERK (extracellular signal-regulated kinase) activity in vascular smooth muscle …

ABSTRACT Introduction: The revised Ghent nosology presents the classical features of
Marfan syndrome. However, behind its familiar face, Marfan syndrome hides less well …

Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

Background: Organ fibrosis due to excessive production of extracellular matrix by resident
fibroblasts is estimated to contribute to> 45% of deaths in the Western world, including those …

Women with Marfan syndrome (MFS) are at high risk for pregnancy-associated aortic
dissection. Pathogenic models that singularly invoke hemodynamic stress are difficult to …

Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of
normal tissue parenchyma with a collagen-rich extracellular matrix produced by …