Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

The lack of in vitro tissue and organ models capable of mimicking human physiology
severely hinders the development and clinical translation of therapies and drugs with higher …

In the field of biomaterials, an endosseous implant is now recognized as an
osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell …

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that
has been associated with several types of cancer. However, its biological significance, as …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

The rheological properties of the extracellular fluid in the female reproductive tract vary
spatiotemporally, however, the effect on the behaviour of epithelial cells that line the tract is …

The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …