An injectable, shape-retaining collagen hydrogel cross-linked using thiol-maleimide click chemistry for sealing corneal perforations

J Rosenquist, M Folkesson, L Höglund… - … Applied Materials & …, 2023 - ACS Publications
Injectable hydrogels show great promise in developing novel regenerative medicine
solutions and present advantages for minimally invasive applications. Hydrogels based on …

Application of collagen I and IV in bioengineering transparent ocular tissues

Y Song, M Overmass, J Fan, C Hodge, G Sutton… - Frontiers in …, 2021 - frontiersin.org
Collagens represent a major group of structural proteins expressed in different tissues and
display distinct and variable properties. Whilst collagens are non-transparent in the skin …

Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment

Y Liu, T Huang, Z Qian, W Chen - Chinese Chemical Letters, 2023 - Elsevier
Microneedles are considered to be an effective, convenient, non-invasive, biosafety and
compliant medical technology for vaccinations, biomarker testing, medical aesthetics and …

LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation

CD McTiernan, FC Simpson, M Haagdorens… - Science …, 2020 - science.org
Transplantation with donor corneas is the mainstay for treating corneal blindness, but a
severe worldwide shortage necessitates the development of other treatment options …

Injectable shape-holding collagen hydrogel for cell encapsulation and delivery cross-linked using thiol-michael addition click reaction

J Pupkaite, J Rosenquist, J Hilborn… - …, 2019 - ACS Publications
Injectable hydrogels based on extracellular matrix-derived polymers show much promise in
the field of tissue engineering and regenerative medicine. However, the hydrogels reported …

In situ-forming collagen hydrogel crosslinked via multi-functional PEG as a matrix therapy for corneal defects

GM Fernandes-Cunha, KM Chen, F Chen, P Le… - Scientific reports, 2020 - nature.com
Visually significant corneal injuries and subsequent scarring collectively represent a major
global human health challenge, affecting millions of people worldwide. Unfortunately, less …

Photocurable gelma adhesives for corneal perforations

IA Barroso, K Man, TE Robinson, SC Cox, AK Ghag - Bioengineering, 2022 - mdpi.com
The current treatments for the management of corneal and scleral perforations include
sutures and adhesives. While sutures are invasive, induce astigmatism and carry a risk of …

Arrested Phase Separation Enables High‐Performance Keratoprostheses

J Pan, W Zhang, J Zhu, J Tan, Y Huang… - Advanced …, 2023 - Wiley Online Library
Corneal transplantation is impeded by donor shortages, immune rejection, and ethical
reservations. Pre‐made cornea prostheses (keratoprostheses) offer a proven option to …

In vivo biocompatibility evaluation of in situ-forming polyethylene glycol-collagen hydrogels in corneal defects

YH Chun, SK Park, EJ Kim, HJ Lee, H Kim, WG Koh… - Scientific reports, 2021 - nature.com
The available treatment options include corneal transplantation for significant corneal
defects and opacity. However, shortage of donor corneas and safety issues in performing …

The effect of the mechanical properties of the 3D printed gelatin/hyaluronic acid scaffolds on hMSCs differentiation towards chondrogenesis

K Choi, CY Park, JS Choi, YJ Kim, S Chung… - Tissue Engineering and …, 2023 - Springer
Background: Tissue engineering, including 3D bioprinting, holds great promise as a
therapeutic tool for repairing cartilage defects. Mesenchymal stem cells have the potential to …