Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

Pyroptosis is increasingly considered a new weathervane in cancer immune therapy.
However, triggering specific pyroptotic tumor cell death while preserving normal cells still …

Copper serves as a vital microelement which is widely present in the biosystem, functioning
as multi-enzyme active site, including oxidative stress, lipid oxidation and energy …

Aim: This study aims to identify pyroptosis-related genes (PRGs), their functional immune
characteristics, and distinct pyroptosis-related clusters in periodontitis. Methods …

Overcoming tumor apoptosis resistance is a major challenge in enhancing cancer therapy.
Pyroptosis, a lytic form of programmed cell death (PCD) involving inflammasomes …

Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median
survival of less than 15 months. However, clinical strategies and effective therapies are …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main
contributor and independent risk factor for low back pain (LBP), it would be, therefore …