ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
The response to poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
The oncogenic helicase ALC1 regulates PARP inhibitor potency by trapping PARP2 at DNA breaks
C Blessing, IK Mandemaker, C Gonzalez-Leal… - Molecular Cell, 2020 - cell.com
The anti-tumor potency of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) has
been linked to trapping of PARP1 on damaged chromatin. However, little is known about …
been linked to trapping of PARP1 on damaged chromatin. However, little is known about …
The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands
T Ahmad, R Kawasumi, T Taniguchi, T Abe… - Nucleic Acids …, 2023 - academic.oup.com
Leading-strand DNA replication by polymerase epsilon (Polϵ) across single-strand breaks
(SSBs) causes single-ended double-strand breaks (seDSBs), which are repaired via …
(SSBs) causes single-ended double-strand breaks (seDSBs), which are repaired via …
XRCC1 counteracts poly (ADP ribose) polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal …
Base excision repair (BER) removes damaged bases by generating single‐strand breaks
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
Chromatin as a platform for modulating the replication stress response
LA Fournier, A Kumar, PC Stirling - Genes, 2018 - mdpi.com
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen
major advances in our understanding of histone supply, histone recycling and nascent …
major advances in our understanding of histone supply, histone recycling and nascent …
CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA …
Chemotherapeutic nucleoside analogs, such as cytarabine (Ara-C), are incorporated into
genomic DNA during replication. Incorporated Ara-CMP (Ara-cytidine monophosphate) …
genomic DNA during replication. Incorporated Ara-CMP (Ara-cytidine monophosphate) …
REV3 promotes cellular tolerance to 5-fluorodeoxyuridine by activating translesion DNA synthesis and intra-S checkpoint
The drug floxuridine (5-fluorodeoxyuridine, FUdR) is an active metabolite of 5-Fluorouracil
(5-FU). It converts to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5 …
(5-FU). It converts to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5 …
Diversity roles of CHD1L in normal cell function and tumorigenesis
X Xiong, X Lai, A Li, Z Liu, N Ma - Biomarker Research, 2021 - Springer
Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a
multifunctional protein participated in diverse cellular processes, including chromosome …
multifunctional protein participated in diverse cellular processes, including chromosome …
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir
Abstract Remdesivir is a 1'-cyano-modified adenine nucleotide analog used for the
treatment of COVID-19. Recently, the anti-carcinogenic effect of remdesivir has been also …
treatment of COVID-19. Recently, the anti-carcinogenic effect of remdesivir has been also …
PrimPol-mediated repriming elicits gap-filling by template switching and promotes cellular tolerance to cidofovir
A nucleoside analog, Cidofovir (CDV), is used for the treatment of viral diseases such as
cytomegalovirus retinitis and herpes virus infection. CDV converts to its active diphosphate …
cytomegalovirus retinitis and herpes virus infection. CDV converts to its active diphosphate …