With the emergence of antibiotic resistance, the interest for antimicrobial agents has recently
increased again in public health. Copper was recognized in 2008 by the United States …

The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …

The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Copper (Cu) is an essential trace element for all aerobic organisms. It functions as a cofactor
in enzymes that catalyze a wide variety of redox reactions due to its ability to cycle between …

Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey …

The bioavailability of different metals has likely changed over the course of Earth's history.
Based on geochemical models, copper became much more bioavailable with the advent of …

The trace element copper is indispensable for all aerobic life forms. Its ability to cycle
between two oxidation states, Cu 1+ and Cu 2+, has been harnessed by a wide array of …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …