Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

[HTML][HTML] Design, clinical translation and immunological response of biomaterials in regenerative medicine

K Sadtler, A Singh, MT Wolf, X Wang… - Nature Reviews …, 2016 - nature.com
The field of regenerative medicine aims to replace tissues lost as a consequence of disease,
trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative …

[HTML][HTML] Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

M Rafat, M Jabbarvand, N Sharma, M Xeroudaki… - Nature …, 2023 - nature.com
Visual impairment from corneal stromal disease affects millions worldwide. We describe a
cell-free engineered corneal tissue, bioengineered porcine construct, double crosslinked …

[HTML][HTML] Mimicking the hierarchical organization of natural collagen: toward the development of ideal scaffolding material for tissue regeneration

L Salvatore, N Gallo, ML Natali, A Terzi… - … in Bioengineering and …, 2021 - frontiersin.org
Biological materials found in living organisms, many of which are proteins, feature a
complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in …

Specialty tough hydrogels and their biomedical applications

S Fuchs, K Shariati, M Ma - Advanced healthcare materials, 2020 - Wiley Online Library
Hydrogels have long been explored as attractive materials for biomedical applications given
their outstanding biocompatibility, high water content, and versatile fabrication platforms into …

Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Preparation and in vitro characterization of cross-linked collagen–gelatin hydrogel using EDC/NHS for corneal tissue engineering applications

H Goodarzi, K Jadidi, S Pourmotabed, E Sharifi… - International journal of …, 2019 - Elsevier
Corneal disease is considered as the second leading cause of vision loss and keratoplasty
is known as an effective treatment for it. However, the tissue engineered corneal substitutes …

[HTML][HTML] Gelatin-based materials in ocular tissue engineering

JB Rose, S Pacelli, AJ El Haj, HS Dua, A Hopkinson… - Materials, 2014 - mdpi.com
Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue
engineering on account of its excellent biocompatibility, ease of processing and availability …

Dental pulp tissue engineering in full-length human root canals

V Rosa, Z Zhang, RHM Grande… - Journal of dental …, 2013 - journals.sagepub.com
The clinical translation of stem-cell-based dental pulp regeneration will require the use of
injectable scaffolds. Here, we tested the hypothesis that stem cells from exfoliated deciduous …

A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study

P Fagerholm, NS Lagali, K Merrett… - Science translational …, 2010 - science.org
Corneas from human donors are used to replace damaged tissue and treat corneal
blindness, but there is a severe worldwide shortage of donor corneas. We conducted a …