Contacts and context that regulate DNA helicase unwinding and replisome progression
HM Perera, MS Behrmann, JM Hoang, WC Griffin… - The Enzymes, 2019 - Elsevier
Hexameric DNA helicases involved in the separation of duplex DNA at the replication fork
have a universal architecture but have evolved from two separate protein families. The …
have a universal architecture but have evolved from two separate protein families. The …
Dynamics of the eukaryotic replicative helicase at lagging-strand protein barriers support the steric exclusion model
Progression of DNA replication depends on the ability of the replisome complex to overcome
nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along …
nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along …
The mechanism of DNA unwinding by the eukaryotic replicative helicase
Accurate DNA replication is tightly regulated in eukaryotes to ensure genome stability during
cell division and is performed by the multi-protein replisome. At the core an AAA+ hetero …
cell division and is performed by the multi-protein replisome. At the core an AAA+ hetero …
An explanation for origin unwinding in eukaryotes
LD Langston, ME O'Donnell - Elife, 2019 - elifesciences.org
Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic
origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand …
origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand …
Supporting evidence for DNA shearing as a mechanism for origin unwinding in eukaryotes
LD Langston, R Georgescu, ME O'Donnell - bioRxiv, 2019 - biorxiv.org
An earlier study demonstrated that head-to-head CMGs that encircle duplex DNA and track
inward, as at origins, melt double-strand (ds) DNA while encircling the duplex by pulling on …
inward, as at origins, melt double-strand (ds) DNA while encircling the duplex by pulling on …
Single-molecule imaging of eukaryotic replisomes reveals compositional plasticity
JS Lewis, LM Spenkelink, GD Schauer, O Yurieva… - bioRxiv, 2019 - biorxiv.org
Duplication of the chromosomal DNA prior to cell division is performed by the replisome, a
multi-protein complex that coordinates a large number of enzymatic activities. The eukaryotic …
multi-protein complex that coordinates a large number of enzymatic activities. The eukaryotic …
Mechanistic Studies of Replication Fork Remodeling by DNA Translocases
GM Warren - 2019 - search.proquest.com
During DNA replication the replication fork can become stalled by impediments that prevent
complete and accurate duplication of the genome. DNA replication fork reversal is an …
complete and accurate duplication of the genome. DNA replication fork reversal is an …