Experimental models play a pivotal role in biomedical research, facilitating the
understanding of disease mechanisms and the development of novel therapeutics. This is …

Radiotherapy (RT), a common cancer treatment, unintentionally harms surrounding tissues,
including the skin, and hinders wound healing years after treatment. This study aims to …

Cryopreservation is a promising technique for the long-term storage of skin. However, the
formation of ice crystals during cryopreservation unavoidably damages skin structure and …

Only half of individuals with suspected rare diseases receive a definitive genetic diagnosis
following genomic testing. A genetic diagnosis allows access to appropriate patient care and …

This protocol introduces a streamlined and efficient method for isolating human fibroblast
from skin primary cell culture with a specific focus on its application to keloid, hypertrophic …

In multicellular organisms, various cells perform distinct physiological and structural roles.
Traditionally, cell identity has been defined through morphological features and molecular …

Disruption of genes within the HNRNP gene family has been observed in
neurodevelopmental and neurodegenerative diseases. The HNRNP-Related …

Mitochondrial beta-oxidation disorders are a group of recessive diseases characterized by
fasting intolerance and symptoms ranging from intermittent myalgia and rhabdomyolysis to …

Study Design This was an in vitro study. Patients who were undergoing surgery for vaginal
prolapse were recruited. Excess vaginal epithelial tissue that would have otherwise been …

The integration of multi-omics techniques has revolutionized the diagnosis of rare genetic
diseases. However, interpreting pediatric variants of uncertain significance (VUS) remains a …