The immune system and the peripheral sensory nervous system communicate through
hardwired and humoral routes using shared mediators and receptors. On the basis of …

Adenosine is a purine nucleoside, responsible for the regulation of multiple physiological
and pathological cellular and tissue functions by activation of four G protein-coupled …

Extracellular nucleosides and nucleotides have widespread functions in responding to
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …

Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important
pain-relieving properties in preclinical settings of several pain models. Active as a …

Physical and emotional pain deteriorates the quality of well-being. Also, numerous non-
invasive and invasive treatments for diagnosed diseases such as cancer medications and …

Neuroimmune–glia interactions have been implicated in the development of neuropathic
pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory …

Pain is a common clinical symptom that seriously affects the quality of life in a variety of
patient populations. In recent years, research on the role of adenosine signaling in pain …

Pain is an essential modality of sensation in the body. Purinergic signaling plays an
important role in nociceptive pain transmission, under both physiological and …

Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing
interest as attractive therapeutic tools for the treatment of a number of pathological …

Despite successful research efforts aimed at understanding pain mechanisms, there is still
no adequate treatment for many patients suffering from chronic pain. The contribution of …