The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …

While the cellular mechanisms of liver regeneration have been thoroughly studied, the role
of extracellular matrix (ECM) in liver regeneration is still poorly understood. We utilized a …

Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that
regulate various pathways that control metabolism and other cellular mechanisms. Various …

Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in acute
kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and …

Background: Cardiac ischemic injury induces a pathological remodeling response, which
can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling …

Diabetic kidney disease (DKD) is the main cause of chronic kidney disease worldwide.
While injury to the podocytes, visceral epithelial cells that comprise the glomerular filtration …

Heart failure is accompanied by adverse cardiac remodeling involving extracellular matrix
(ECM). Cardiac ECM acts as a major reservoir for many proteins including growth factors …

Abstract Thrombospondin-4 (TSP-4) belongs to the thrombospondin protein family that
consists of five highly homologous members. A number of novel functions have been …

Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various
pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 …