Capsaicin and TRPV1 channels in the cardiovascular system: the role of inflammation

S Munjuluri, DA Wilkerson, G Sooch, X Chen, FA White… - Cells, 2021 - mdpi.com
Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1)
channel and is a common component found in the fruits of the genus Capsicum plants …

Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport

M Oz, DE Lorke, FC Howarth - Medicinal Research Reviews, 2023 - Wiley Online Library
Capsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its
hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including …

[HTML][HTML] Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent …

S Negri, P Faris, G Tullii, M Vismara, AF Pellegata… - Cell Calcium, 2022 - Elsevier
Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …

Modulating effects of capsaicin on glucose homeostasis and the underlying mechanism

W Liang, Y Lan, C Chen, M Song, J Xiao… - Critical Reviews in …, 2023 - Taylor & Francis
Abnormal glucose homeostasis is linked to a variety of metabolic syndromes, such as insulin
resistance, obesity, type-2 diabetes mellitus, hypertension and cardiovascular diseases …

Synthesis of dihydropyrimidines: Isosteres of nifedipine and evaluation of their calcium channel blocking efficiency

YM Zohny, SM Awad, MA Rabie, OA Al-Saidan - Molecules, 2023 - mdpi.com
Hypertension and cardiovascular diseases related to it remain the leading medical
challenges globally. Several drugs have been synthesized and commercialized to manage …

TRPV1 contributes to modulate the nitric oxide pathway and oxidative stress in the isolated and perfused rat heart during ischemia and reperfusion

V Castrejón-Téllez, L del Valle-Mondragón… - Molecules, 2022 - mdpi.com
The transient vanilloid receptor potential type 1 (TRPV1) regulates neuronal and vascular
functions mediated by nitric oxide (NO) and by the calcitonin gene-related peptide (CGRP) …

Functional Analysis of TRPA1, TRPM3, and TRPV1 Channels in Human Dermal Arteries and Their Role in Vascular Modulation

E Rivera-Mancilla, L Al-Hassany, H Marynissen… - Pharmaceuticals, 2024 - mdpi.com
Transient receptor potential (TRP) channels are pivotal in modulating vascular functions. In
fact, topical application of cinnamaldehyde or capsaicin (TRPA1 and TRPV1 channel …

Contribution of transient receptor potential vanilloid 1 (TRPV1) channel to cholinergic contraction of rat bladder smooth muscle

BR Sharopov, IB Philyppov, SI Yeliashov… - The Journal of …, 2024 - Wiley Online Library
Transient receptor potential vanilloid 1 (TRPV1) is a calcium‐permeable ion channel that is
gated by the pungent constituent of red chili pepper, capsaicin, and by related chemicals …

Cultured rat aortic vascular smooth muscle cells do not express a functional TRPV1

T Blažević, CI Ciotu, M Gold-Binder, EH Heiss… - Plos one, 2023 - journals.plos.org
We showed previously that capsaicin, an active compound of chili peppers, can inhibit
platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle …

Garlic prevents the oxidizing and inflammatory effects of sepsis induced by bacterial lipopolysaccharide at the systemic and aortic level in the rat. Role of trpv1

JC Torres-Narváez, I Pérez-Torres… - Heliyon, 2023 - cell.com
Garlic (Allium sativum) possesses healing properties for diseases like systemic arterial
hypertension, cancer and diabetes, among others. Its main component, allicin, binds to the …