The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …

INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …

Background & Aims Cancer-associated fibroblasts (CAFs) play an important role in
colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However …

Many cancer patients suffer from metastatic relapse several years after they have undergone
radical surgery. Early cancer cell dissemination followed by a protracted period of dormancy …

The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial
cells transdifferentiate into mesenchymal cells in the developmental stage, known as …

The existence of adult pancreatic progenitor cells has been debated. While some favor the
concept of facultative progenitors involved in homeostasis and repair, neither a location nor …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Kras-activating mutations display the highest incidence in pancreatic ductal
adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in …

Background and aims Pancreatic ductal adenocarcinoma (PDAC) is characterized by a
fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown …