Oxygen-and sulphur-containing heterocyclic compounds as potential anticancer agents

H Sachdeva, S Khaturia, M Saquib, N Khatik… - Applied Biochemistry …, 2022 - Springer
Oxygen-and sulphur-based heterocycles form the core structure of many biologically active
molecules as well as US FDA-approved drugs. Moreover, they possess broad range of …

Naturally Occurring Organohalogen Compounds—A Comprehensive Review

GW Gribble - Naturally Occurring Organohalogen Compounds, 2023 - Springer
The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

Natural products of marine origin for the treatment of colorectal and pancreatic cancers: mechanisms and potential

N Fares Amer, T Luzzatto Knaan - International Journal of Molecular …, 2022 - mdpi.com
Gastrointestinal cancer refers to malignancy of the accessory organs of digestion, and it
includes colorectal cancer (CRC) and pancreatic cancer (PC). Worldwide, CRC is the …

[HTML][HTML] A Close View of the Production of Bioactive Fungal Metabolites Mediated by Chromatin Modifiers

JA Takahashi, LL de Queiroz, DM Vidal - Molecules, 2024 - mdpi.com
Secondary metabolites produced by fungi are well known for their biological properties,
which play important roles in medicine. These metabolites aid in managing infections and …

[HTML][HTML] The anticancer and antioxidant potential of local sea cucumber Holothuria edulis, an ecology balancer of Labuan Bajo marine ecosystem

I Winarni, T Murniasih, E Novriyanti, K Tarman… - Case Studies in …, 2024 - Elsevier
Sea cucumbers are marine animals that contribute to the balance of marine ecosystems.
Moreover, due to their secondary metabolites, they have biological activities such as …

A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase

K Zhang, J Liang, B Zhang, L Huang, J Yu, X Xiao… - Molecules, 2024 - mdpi.com
The Zika virus (ZIKV) is a mosquito-borne virus that already poses a danger to worldwide
human health. Patients infected with ZIKV generally have mild symptoms like a low-grade …

5-epi-Sinuleptolide from Soft Corals of the Genus Sinularia Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK …

WC Tsai, WH Wang, BC Huang, CY Huang, JH Sheu - Molecules, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of
patients are diagnosed with a metastatic disease, which is associated with a five-year …

Chemical and Biological Characterization of the Ethyl Acetate Fraction from the Red Sea Marine Sponge Hymedesmia sp.

ZI El Sayed, WHB Hassan, MM Abdel-Aal… - Pharmaceuticals, 2024 - mdpi.com
Hymedesmiidae is one of the largest families of marine sponges and stands out as an
exceptional source of variable metabolites with diverse biological activities. In this study, the …

[HTML][HTML] Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases

EKE Anwer, M Ajagbe, M Sherif, AS Musaibah… - …, 2025 - pmc.ncbi.nlm.nih.gov
The gut microbiota, a dynamic ecosystem of trillions of microorganisms, produces secondary
metabolites that profoundly influence host health. Recent research has highlighted the …

[HTML][HTML] Polyketides from Plakortis Sponges around Caribbean Coastal Regions: Collection, Isolation, Characterization, and Bioactivity

RR Rodríguez-Berríos, JA Rodríguez-Vargas… - Coasts, 2024 - mdpi.com
The coastal region of the Caribbean is notable for the chemical diversity found in its sponge
products, resulting in the biosynthesis of a range of natural marine products, including …