This review is an attempt to compile the literature of various synthetic procedures of
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …

The synthesis of a series of 3-(4-chlorophenyl)-[1, 2-c] pyrazol (in) es substituted with
benzenesulfonamide, N1, N3-disubstituted sulfonylurea, sulfonylthiourea pharmacophores …

Abstract Thiazolo [4, 5-d] pyrimidines are fused heterocyclic ring-systems that can be viewed
at the first glance as purine isosteres. They are the 7 thia-analogs of purines via the …

Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical
DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in …

The azole pharmacophore is still considered a viable lead structure for the synthesis of more
efficacious and broad spectrum antimicrobial agents. Potential antibacterial and antifungal …

New 1-thia-azaspiro [4.5] decane derivatives, their derived thiazolopyrimidine and 1, 3, 4-
thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized …

Synthesis and antifungal activity of hybrids of thiazolo [4, 5-d] pyrimidines with (1H-1, 2, 4)
triazoles are presented. The solubility and lipophilicity of compounds was assessed and it …

We report on the synthesis and biological evaluation of two series of 2, 4, 5‐polysubstituted
thiazoles comprising the acid hydrazide functionality and some derived pharmacophores …

The synthesis of a series of certain polymethoxy chalcones and some derived pyrazole,
pyrimidine, and thiazolopyrimidine ring structures is reported. Eleven compounds 4, 6, 9, 11 …

The synthesis of two novel series of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazoles linked to
either polysubstituted 1H-pyrazole counterparts through a carbonyl bridge, or to some …