Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive
tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA …

The proteins belonging to the inhibitor of growth (ING) family of proteins serve as epigenetic
readers of the H3K4Me3 histone mark of active gene transcription and target histone …

Gene expression is regulated by a number of interrelated posttranslational modifications of
histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts …

Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in
malignant transformation. We investigated the clinical significance of miR-650 and its …

Abstract ING genes (ING1–5) were identified has tumor suppressor genes. ING proteins are
characterized as Type II TSGs since they are involved in the control of cell proliferation …

Background In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate
dysregulation of miRNAs expression. For instance, miR‐650 has been implicated in gastric …

Wang Q‐s, Li M, Zhang L‐y, Jin Y, Tong D‐d, Yu Y, Bai J, Huang Q, Liu F‐L, Liu A, Lee K‐Y
& Fu S‐b (2010) Histopathology 57, 271–281 Down‐regulation of ING4 is associated with …

Nuclear Factor kappa B (NF-κB) is a key mediator of normal immune response but
contributes to aggressive cancer cell phenotypes when aberrantly activated. Here we …

ING5 can interact with p53, thereby inhibiting cell growth and inducing apoptosis. To clarify
the roles of ING5 in gastric tumorigenesis and progression, its expression was examined by …

Abstract The INhibitor of Growth (ING) family is an evolutionarily conserved set of proteins,
implicated in suppression of initiation and progression of cancers in various tissues. They …