Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Site specific N-and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concern
The glycosylation on the spike (S) protein of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, modulates the viral infection …
coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, modulates the viral infection …
Restoring protein glycosylation with GlycoShape
Despite ground-breaking innovations in experimental structural biology and protein structure
prediction techniques, capturing the structure of the glycans that functionalize proteins …
prediction techniques, capturing the structure of the glycans that functionalize proteins …
[HTML][HTML] Principles of SARS-CoV-2 glycosylation
The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity
Q Yang, A Kelkar, A Sriram, R Hombu, TA Hughes… - Science …, 2022 - science.org
Functional and epidemiological data suggest that N-linked glycans on the SARS-CoV-2
Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to …
Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to …
Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants
S Lusvarghi, CB Stauft, R Vassell, B Williams… - PLoS …, 2023 - journals.plos.org
The SARS-CoV-2 spike glycoprotein has 22 potential N-linked glycosylation sites per
monomer that are highly conserved among diverse variants, but how individual glycans …
monomer that are highly conserved among diverse variants, but how individual glycans …
COVID‐19 metabolism: Mechanisms and therapeutic targets
T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …
signaling, immune response, and cell metabolism in human body. Viral genome and …
Post-translational modification of PD-1: potential targets for Cancer Immunotherapy
TA Lee, EY Tsai, SH Liu, SD Hsu Hung, SJ Chang… - Cancer Research, 2024 - AACR
Activation of effector T cells leads to upregulation of PD-1, which can inhibit T cell activity
following engagement with its ligand PD-L1. Post-translational modifications (PTMs) …
following engagement with its ligand PD-L1. Post-translational modifications (PTMs) …
Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis
Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …