Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics

W Gao, Y Xiong, Q Li, H Yang - Frontiers in physiology, 2017 - frontiersin.org
The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …

Chemical basis of interactions between engineered nanoparticles and biological systems

Q Mu, G Jiang, L Chen, H Zhou, D Fourches… - Chemical …, 2014 - ACS Publications
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …

Identifying trends in gold nanoparticle toxicity and uptake: size, shape, capping ligand, and biological corona

C Carnovale, G Bryant, R Shukla, V Bansal - ACS omega, 2019 - ACS Publications
The drive behind the growing interest in understanding gold nanoparticle (AuNP) cytotoxicity
originates from the promise of AuNPs for diverse biological applications across the fields of …

[HTML][HTML] Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

L Yao, D Bojic, M Liu - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Use of gold nanoparticles (GNPs) in medicine is an emerging field of translational research
with vast clinical implications and exciting therapeutic potential. However, the safety of using …

The gold standard: gold nanoparticle libraries to understand the nano–bio interface

AM Alkilany, SE Lohse, CJ Murphy - Accounts of chemical …, 2013 - ACS Publications
Since the late 1980s, researchers have prepared inorganic nanoparticles of many types
including elemental metals, metal oxides, metal sulfides, metal selenides, and metal …

Uptake of engineered gold nanoparticles into mammalian cells

LA Dykman, NG Khlebtsov - Chemical reviews, 2014 - ACS Publications
In the past decade, mammalian cells have increasingly encountered gold nanoparticles
(GNPs), owing to the active development of nanomedicine. 1− 3 GNPs have been more and …

Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

J Zong, SL Cobb, NR Cameron - Biomaterials science, 2017 - pubs.rsc.org
Colloidal gold solutions have been used for centuries in a wide variety of applications
including staining glass and in the colouring of ceramics. More recently, gold nanoparticles …

Fluorous‐Tagged Peptide Nanoparticles Ameliorate Acute Lung Injury via Lysosomal Stabilization and Inflammation Inhibition in Pulmonary Macrophages

K Wang, G Rong, Y Gao, M Wang, J Sun, H Sun, X Liao… - Small, 2022 - Wiley Online Library
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common respiratory
critical syndrome that currently has no effective therapeutic interventions. Pulmonary …

Towards understanding of nanoparticle–protein corona

C Ge, J Tian, Y Zhao, C Chen, R Zhou, Z Chai - Archives of toxicology, 2015 - Springer
With the rapid developments of nanotechnology, chances of exposing nanoscale particles to
humans (eg, workers and consumers) also increase correspondingly, which raises serious …

Surface functionality of nanoparticles determines cellular uptake mechanisms in mammalian cells

K Saha, ST Kim, B Yan, OR Miranda, FS Alfonso… - Small, 2013 - Wiley Online Library
Nanoparticles (NPs) are versatile scaffolds for numerous biomedical applications including
drug delivery and bioimaging. The surface functionality of NPs essentially dictates …