This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

Mutations that drive uncontrolled cell-cycle progression are requisite events in
tumorigenesis. But evolution has installed in the proliferative programmes of mammalian …

In multicellular organisms, the total number of cells is a balance between the cell-generating
effects of mitosis and cell death that is induced through apoptosis. A disruption of this …

Although lymphoma is a very heterogeneous group of biologically complex malignancies,
tumor cells across all B cell lymphoma subtypes share a set of underlying traits that promote …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

Abstract c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its
abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes …

The Bcl-2 family consists of about 20 homologues of important pro-and anti-apoptotic
regulators of programmed cell death. The established mode of function of the individual …

Defects in the apoptosis mechanism stimulate cancer cell growth and survival. B cell
lymphoma 2 (Bcl-2) is an anti-apoptotic molecule that plays a central role in apoptosis. Bcl-2 …

Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …