[HTML][HTML] Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Contribution of STAT3 to the pathogenesis of COVID-19

A Jafarzadeh, M Nemati, S Jafarzadeh - Microbial pathogenesis, 2021 - Elsevier
Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine
storm, large viral replication and massive cell death play fundamental roles in the …

Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics …

O Jung, YT Tung, E Sim, YC Chen, E Lee… - …, 2022 - iopscience.iop.org
The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay
platforms for efficient discovery and development of antivirals and disease-modulating …

[HTML][HTML] Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

H Que, W Hong, T Lan, H Zeng, L Chen… - Signal transduction and …, 2022 - nature.com
Abstract For coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), 15–30% of patients are likely to develop COVID-19 …

[HTML][HTML] Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells

D Kim, S Maharjan, M Kang, J Kim, S Park… - Frontiers in …, 2022 - frontiersin.org
Stress granule formation is induced by numerous environmental stressors, including sodium
arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral …

[HTML][HTML] Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2

D Kim, J Kim, M Kim, H Park, S Park… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The spectrum of SARS-CoV-2 mutations have increased over time, resulting in
the emergence of several variants of concern. Persistent infection is assumed to be involved …

In vitro and in vivo suppression of SARS‐CoV‐2 replication by a modified, short, cell‐penetrating peptide targeting the C‐terminal domain of the viral spike protein

D Kim, J Kim, S An, M Kim, K Baek… - Journal of Medical …, 2023 - Wiley Online Library
Peptides are promising therapeutic agents for COVID‐19 because of their specificity, easy
synthesis, and ability to be fine‐tuned. We previously demonstrated that a cell‐permeable …

[HTML][HTML] Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

X Lin, B Fu, Y Xiong, N Xing, W Xue, D Guo… - PLoS …, 2023 - journals.plos.org
Coronavirus disease 2019 is a respiratory infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence on the pathogenesis of SARS …

[HTML][HTML] Production of a monoclonal antibody to the nucleocapsid protein of SARS-CoV-2 and its application to ELISA-based detection methods with broad specificity …

J Kim, D Kim, K Baek, M Kim, BM Kang, S Maharjan… - Viruses, 2022 - mdpi.com
The coronavirus disease 2019 pandemic, elicited by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is ongoing. Currently accessible antigen-detecting rapid …

[HTML][HTML] Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production …

SL Faley, NA Boghdeh, DK Schaffer, EC Spivey… - Lab on a Chip, 2024 - pubs.rsc.org
Human microphysiological systems, such as organs on chips, are an emerging technology
for modeling human physiology in a preclinical setting to understand the mechanism of …