NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
Neuronal cell death
M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …
especially important because of the limited capacity of adult neurons to proliferate or be …
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
L Rajman, K Chwalek, DA Sinclair - Cell metabolism, 2018 - cell.com
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
NAD+ intermediates: the biology and therapeutic potential of NMN and NR
Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …
insights into the pathogenesis of age-associated functional decline and diseases. In …
Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
[HTML][HTML] Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
Programmed axon degeneration: from mouse to mechanism to medicine
MP Coleman, A Höke - Nature Reviews Neuroscience, 2020 - nature.com
Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1
Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …