Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Transfer function analysis of dynamic cerebral autoregulation: a CARNet white paper 2022 update

RB Panerai, P Brassard, JS Burma… - Journal of Cerebral …, 2023 - journals.sagepub.com
Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Transfer function analysis of dynamic cerebral autoregulation: a white paper from the International Cerebral Autoregulation Research Network

JAHR Claassen… - Journal of Cerebral …, 2016 - journals.sagepub.com
Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral
perfusion in the presence of blood pressure changes. A large number of methods to assess …

Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome

RC Nogueira, M Aries, JS Minhas… - Journal of Cerebral …, 2022 - journals.sagepub.com
Acute stroke is associated with high morbidity and mortality. In the last decades, new
therapies have been investigated with the aim of improving clinical outcomes in the acute …

Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research …

K Kostoglou, F Bello-Robles… - Journal of Cerebral …, 2024 - journals.sagepub.com
Cerebral Autoregulation (CA) is an important physiological mechanism stabilizing cerebral
blood flow (CBF) in response to changes in cerebral perfusion pressure (CPP). By …

Further understanding of cerebral autoregulation at the bedside: possible implications for future therapy

J Donnelly, MJ Aries, M Czosnyka - Expert review of …, 2015 - Taylor & Francis
Cerebral autoregulation reflects the ability of the brain to keep the cerebral blood flow (CBF)
relatively constant despite changes in cerebral perfusion pressure. It is an intrinsic …

Effects of nilvadipine on cerebral blood flow in patients with Alzheimer disease: a randomized trial

DLK de Jong, RAA de Heus, A Rijpma, R Donders… - …, 2019 - Am Heart Assoc
Cerebrovascular changes, including reduced cerebral blood flow (CBF), occur early in the
development of Alzheimer disease and may accelerate disease progression. This …

Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: a systematic review of the methodology

MH Olsen, CG Riberholt, J Mehlsen… - Journal of Cerebral …, 2022 - journals.sagepub.com
Cerebral autoregulation is a complex mechanism that serves to keep cerebral blood flow
relatively constant within a wide range of cerebral perfusion pressures. The mean flow index …

Resistance, but not endurance exercise training, induces changes in cerebrovascular function in healthy young subjects

HJ Thomas, CE Marsh, LH Naylor… - American Journal …, 2021 - journals.physiology.org
It is generally considered that regular exercise maintains brain health and reduces the risk of
cerebrovascular diseases such as stroke and dementia. Since the benefits of different …

Assessment of cerebral autoregulation indices–a modelling perspective

X Liu, M Czosnyka, J Donnelly, D Cardim… - Scientific reports, 2020 - nature.com
Various methodologies to assess cerebral autoregulation (CA) have been developed,
including model-based methods (eg autoregulation index, ARI), correlation coefficient …