Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …

Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Selective serotonin reuptake inhibitors are the mostly widely used treatment for major
depressive disorders and also are prescribed for several anxiety disorders. However, similar …

Depression is a serious global illness, becoming more and more common in developed
countries. Because of specific symptoms it is considered as a leading cause of disability all …

Background Between 30 and 50% of patients with major depressive disorder (MDD) do not
respond sufficiently to antidepressant regimens. The conventional pharmacological …

Mood disorders such as major depression are common illnesses with considerable
morbidity and significant mortality. A long-standing theory is that a breakdown in brain …

Importance The cerebral serotonin 4 (5-HT 4) receptor is a promising novel target for
treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT …

The existence of a high co-morbidity between Alzheimer's disease (AD) and depression has
been known for a long time. More interesting though are recent studies indicating that …

Identification of a biomarker that can inform on extracellular serotonin (5-HT) levels in the
brains of living humans would enable greater understanding of the way brain circuits are …