Seeking heterocyclic scaffolds as antivirals against dengue virus
Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Drug repurposing: A strategy for discovering inhibitors against emerging viral infections
IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …
past few years, the world has seen several outbreaks caused by viral diseases that, for a …
Dengue virus: pathogenesis and potential for small molecule inhibitors
N Chauhan, KK Gaur, TR Asuru… - Bioscience reports, 2024 - portlandpress.com
Dengue, caused by dengue virus (DENV), is now endemic in nearly 100 countries and
infection incidence is reported in another 30 countries. Yearly an estimated 400 million …
infection incidence is reported in another 30 countries. Yearly an estimated 400 million …
Structure-based design of antivirals against envelope glycoprotein of dengue virus
Dengue virus (DENV) presents a significant threat to global public health with more than
500,000 hospitalizations and 25,000 deaths annually. Currently, there is no clinically …
500,000 hospitalizations and 25,000 deaths annually. Currently, there is no clinically …
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors
B Kesteleyn, D Bardiot, JF Bonfanti… - Journal of Medicinal …, 2023 - ACS Publications
In the absence of any approved dengue-specific treatment, the discovery and development
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …
The fellowship of privileged scaffolds—One structure to inhibit them all
M Skoreński, M Sieńczyk - Pharmaceuticals, 2021 - mdpi.com
Over the past few years, the application of privileged structure has emerged as a powerful
approach to the discovery of new biologically active molecules. Privileged structures are …
approach to the discovery of new biologically active molecules. Privileged structures are …
Anti-dengue therapeutic potential of Tinospora cordifolia and its bioactives
Ethnopharmacological relevance Dengue is one of the most prevalent mosquito-borne viral
infections. Moreover, due to the absence of appropriate curative and preventive measures …
infections. Moreover, due to the absence of appropriate curative and preventive measures …
Discovery of a potent and selective chikungunya virus envelope protein inhibitor through computer-aided drug design
L Battini, DM Fidalgo, DE Álvarez… - ACS Infectious …, 2021 - ACS Publications
The worldwide expansion of chikungunya virus (CHIKV) into tropical and subtropical areas
in the last 15 years has posed a currently unmet need for vaccines and therapeutics. The E2 …
in the last 15 years has posed a currently unmet need for vaccines and therapeutics. The E2 …
From De Novo Design to Redesign: Harnessing Computational Protein Design for Understanding SARS-CoV-2 Molecular Mechanisms and Developing Therapeutics
The continuous emergence of novel SARS-CoV-2 variants and subvariants serves as
compelling evidence that COVID-19 is an ongoing concern. The swift, well-coordinated …
compelling evidence that COVID-19 is an ongoing concern. The swift, well-coordinated …
Targeting a conserved pocket (n-octyl-β-D–glucoside) on the dengue virus envelope protein by small bioactive molecule inhibitors
P Naresh, A Selvaraj, P Shyam Sundar… - Journal of …, 2022 - Taylor & Francis
Dengue virus enters the cell by receptor-mediated endocytosis followed by a viral envelope
(DENVE) protein-mediated membrane fusion. A small detergent molecule n-octyl-β-D …
(DENVE) protein-mediated membrane fusion. A small detergent molecule n-octyl-β-D …