Children and adolescents with overweight and obesity are a global health concern. This is
an integrative overview of six Cochrane systematic reviews, providing an up-to-date …

A growing number of youth suffer from obesity and in particular severe obesity for which
intensive lifestyle intervention does not adequately reduce excess adiposity. A treatment gap …

Background Diagnosing polycystic ovary syndrome (PCOS) during adolescence is
challenging because features of normal pubertal development overlap with adult diagnostic …

EXECUTIVE SUMMARY Polycystic Ovary Syndrome (PCOS) is recognized as the most
common endocrine disorder of reproductive-aged women around the world. This document …

We asked whether pharmacological stimulation of endogenous neural precursor cells
(NPCs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in …

Importance Childhood obesity is an important public health problem with increasing
prevalence. Because treatment often has limited success, new approaches must be …

Background Child and adolescent obesity has increased globally, and can be associated
with significant short‐and long‐term health consequences. Objectives To assess the efficacy …

Background Studies have demonstrated a reduction for otitis media (OM) following the
introduction of seven-valent pneumococcal conjugate vaccine (PCV7), but this has not been …

Context: Childhood obesity is increasingly associated with type 2 diabetes (T2D). Metformin
reduces the risk for T2D in adult obese nondiabetic patients, but the evidence in obese …

Results Oligo-anovulation in adolescents, if persistent, is a matter for concern. Hirsutism and
moderate to severe acne in adolescent females should be considered as clinical …