Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and
usually has its onset during youth. Its chronic course is associated with high rates of …

A recent worldwide survey in 11 countries found a median age of onset of about 25 years, 3
with an overall lifetime prevalence of 0.6% for bipolar I disorder (male predominance …

Objectives To examine (i) the frequency of different sleep complaints (early wake-up, trouble
falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic …

Objective: The authors sought to identify diagnostic risk factors of manic, mixed, or
hypomanic episodes in the offspring of parents with bipolar disorder (“high-risk offspring”) …

BackgroundBipolar disorder is highly heritable and therefore longitudinal observation of
children of affected parents is important to mapping the early natural history. AimsTo model …

Objective: The authors sought to assess dimensional symptomatic predictors of new-onset
bipolar spectrum disorders in youths at familial risk of bipolar disorder (“at-risk” youths) …

Objective We discuss the rationale behind staging systems described specifically for bipolar
disorders. Current applications, future directions and research gaps in clinical staging …

Most mental illnesses emerge during adolescence and early adulthood, with considerable
associated distress and functional decline appearing during this critical developmental …

Objective Offspring of bipolar parents have a genetically increased risk of developing mood
disorders. In a longitudinal study, the authors followed a bipolar offspring cohort from …

Background: Recent studies have identified a Child Behavior Checklist profile that
characterizes children with severe affective and behavioral dysregulation (CBCL …