Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

A groundbreaking study into the formative role of play in our lives Sergio and Vivien Pellis
have synthesized three decades of empirical research to create a remarkable work …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Early life stress (ELS) developmental effects have been widely studied by preclinical
researchers. Despite the growing body of evidence from ELS models, such as the maternal …

This paper integrates the cumulative stress hypothesis with the mismatch hypothesis, taking
into account individual differences in sensitivity to programming. According to the cumulative …

Significance: Severe life stress (SLS), as opposed to trivial everyday stress, is defined as a
serious psychosocial event with the potential of causing an impacting psychological …

Rationale Early life stress has been implicated in many psychiatric disorders ranging from
depression to anxiety. Maternal separation in rodents is a well-studied model of early life …

The ability to modify mice genetically has been one of the major breakthroughs in modern
medical science affecting every discipline including psychiatry. It is hoped that the …

Dogs perform a variety of integral roles in our society, engaging in work ranging from
assistance (eg service dogs, guide dogs) and therapy to detection (eg search and rescue …