Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Neuroendocrinology of reproduction in teleost fish

Y Zohar, JA Muñoz-Cueto, A Elizur, O Kah - General and comparative …, 2010 - Elsevier
This review aims at synthesizing the most relevant information regarding the
neuroendocrine circuits controlling reproduction, mainly gonadotropin release, in teleost …

Kisspeptin signaling in the brain

AE Oakley, DK Clifton, RA Steiner - Endocrine reviews, 2009 - academic.oup.com
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse

VM Navarro, ML Gottsch, C Chavkin… - Journal of …, 2009 - Soc Neuroscience
Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in
reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive …

Distribution of kisspeptin neurones in the adult female mouse brain

J Clarkson, X D'Anglemont de Tassigny… - Journal of …, 2009 - Wiley Online Library
Kisspeptin‐GPR54 signalling is essential for normal reproductive functioning. However, the
distribution of kisspeptin neuronal cell bodies and their projections is not well established …

Kisspeptin neurons and estrogen–estrogen receptor α signaling: unraveling the mystery of steroid feedback system regulating mammalian reproduction

Y Uenoyama, N Inoue, S Nakamura… - International journal of …, 2021 - mdpi.com
Estrogen produced by ovarian follicles plays a key role in the central mechanisms
controlling reproduction via regulation of gonadotropin-releasing hormone (GnRH) release …

Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects

MN Lehman, SM Hileman, RL Goodman - Kisspeptin signaling in …, 2013 - Springer
Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of
the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will …

Discovery and evolutionary history of gonadotrophin‐inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction

K Tsutsui, GE Bentley, LJ Kriegsfeld… - Journal of …, 2010 - Wiley Online Library
Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …

Anatomy of the kisspeptin neural network in mammals

MN Lehman, CM Merkley, LM Coolen, RL Goodman - Brain research, 2010 - Elsevier
Kisspeptin has been recognized as a key regulator of GnRH secretion during puberty and
adulthood, conveying the feedback influence of endogenous gonadal steroids onto the …

[HTML][HTML] Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours

M Sivalingam, IS Parhar - Frontiers in neuroendocrinology, 2022 - Elsevier
Kisspeptin, encoded by the KISS1 gene, was first discovered as a potential metastasis
suppressor gene. The prepro-kisspeptin precursor is cleaved into shorter mature bioactive …