Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Glial connexins and pannexins in the healthy and diseased brain

C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet

C Liu, N Zhang, R Zhang, L Jin… - Journal of Agricultural …, 2020 - ACS Publications
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Recently, ketogenic diet (KD) supplementation has attracted great …

[HTML][HTML] Recent insights into astrocytes as therapeutic targets for demyelinating diseases

RP Gorter, W Baron - Current Opinion in Pharmacology, 2022 - Elsevier
Astrocytes are a group of glial cells that exhibit great morphological, transcriptional and
functional diversity both in the resting brain and in response to injury. In recent years …

Natural aporphine alkaloids with potential to impact metabolic syndrome

FX Wang, N Zhu, F Zhou, DX Lin - Molecules, 2021 - mdpi.com
The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As
a major risk factor for various diseases, metabolic syndrome has come into focus in recent …

Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression

H Wang, Y Yang, S Yang, S Ren, J Feng… - Frontiers in …, 2021 - frontiersin.org
Depression is an inflammation-associated disease that results in major depression as
inflammation increases and progresses. Ginsenoside Rg1 (Rg1), the major bioactive …

Interactions between astrocytes and oligodendroglia in myelin development and related brain diseases

X Hu, G Yu, X Liao, L Xiao - Neuroscience Bulletin, 2023 - Springer
Astrocytes (ASTs) and oligodendroglial lineage cells (OLGs) are major macroglial cells in
the central nervous system. ASTs communicate with each other through connexin (Cx) and …

[HTML][HTML] Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis

S Theophanous, I Sargiannidou, KA Kleopa - International Journal of …, 2024 - mdpi.com
Even though several highly effective treatments have been developed for multiple sclerosis
(MS), the underlying pathological mechanisms and drivers of the disease have not been …

Nano‐selenium alleviates cadmium‐induced neurotoxicity in cerebrum via inhibiting gap junction protein connexin 43 phosphorylation

YR Xu, M Talukder, CX Li, YX Zhao… - Environmental …, 2024 - Wiley Online Library
Cadmium (Cd) as a ubiquitous toxic heavy metal is reported to affect the nervous system.
Selenium (Se) has been shown to have antagonistic effects against heavy metal toxicity. In …

Connexins signatures of the neurovascular unit and their physio-pathological functions

N Vicario, R Parenti - International Journal of Molecular Sciences, 2022 - mdpi.com
Central nervous system (CNS) homeostasis is closely linked to the delicate balance of the
microenvironment in which different cellular components of the neurovascular unit (NVU) …