Preclinical studies of primary cancer cells are typically done after tumors are removed from
patients or animals at ambient atmospheric oxygen (O2,~ 21%). However, O2 …

In humans, the adaptive immune system uses the exchange of information between cells to
detect and eliminate foreign or damaged cells; however, the removal of unwanted cells does …

Histologically normal tissue adjacent to the tumor can provide insight of the
microenvironmental alterations surrounding the cancerous lesion and affecting the …

The biologic basis of genetic ancestry-dependent variability in disease incidence and
outcome is just beginning to be explored. We recently reported enrichment of a population of …

Study of genomic aberrations leading to immortalization of epithelial cells has been
technically challenging due to the lack of isogenic models. To address this, we used healthy …

Background Family with sequence similarity 83 member A (FAM83A) presents oncogenic
properties in several cancers including breast cancer. Recently, we reported FAM83A …

Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer
metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions …

SMAD pathways govern epithelial proliferation, and transforming growth factor β (TGF-β and
BMP signaling through SMAD members has distinct effects on mammary development and …

Radiologic techniques remain the main method for early detection for breast cancer and are
critical to achieve a favorable outcome from cancer. However, more sensitive detection …

Drug resistance is a major barrier against successful treatments of cancer patients. Gain of
stemness under drug pressure is a major mechanism that renders treatments ineffective …