Biology and pathology of the uterine microenvironment and its natural killer cells

F Wang, AE Qualls, L Marques-Fernandez… - Cellular & molecular …, 2021 - nature.com
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

O Huhn, MA Ivarsson, L Gardner, M Hollinshead… - Nature …, 2020 - nature.com
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding
maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass …

Intra-and extracellular effector vesicles from human T and NK cells: same-same, but different?

M Lettau, O Janssen - Frontiers in Immunology, 2021 - frontiersin.org
Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells utilize an overlapping effector
arsenal for the elimination of target cells. It was initially proposed that all cytotoxic effector …

Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease

V Persic, AL Bastiancic, I Rosovic, D Raljevic… - Medical hypotheses, 2018 - Elsevier
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol,
high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised …

The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for Vδ2+ γδ T cells in the …

EL Sparrow, DW Fowler, J Fenn, J Caron… - …, 2020 - Wiley Online Library
Release of granulysin by γδ T cells contributes to tumour cell killing. A cytolytic 9000 MW
isoform of granulysin kills tumour cells directly, whereas a 15 000 MW precursor has been …

Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation

M Lettau, M Dietz, K Dohmen, M Leippe, D Kabelitz… - Molecular …, 2019 - Elsevier
Granulysin (GNLY) is a cationic antimicrobial, proinflammatory, and cytotoxic effector protein
primarily expressed in human cytotoxic T and NK cells. Its two variants, the 15 kDa precursor …

Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery

S Jadranko, VS Tokmadzic, K Danijel, M Igor… - Medical hypotheses, 2017 - Elsevier
When medication management or percutaneous coronary intervention is not successful in
patients with advanced ischemic heart disease, surgical revascularisation—predominantly …

Potential role of heat‐shock protein 70 and interleukin‐15 in the pathogenesis of threatened spontaneous abortions

T Gulic, G Laskarin, M Dominovic… - American journal of …, 2016 - Wiley Online Library
Problem The role of HSP 70 and both its constitutive (H sc) and inducible (H sp) forms in the
pathogenesis of threatened spontaneous abortions was investigated. Method of study …

Granulysin‐mediated apoptosis of trophoblasts in blighted ovum and missed abortion

T Gulic, G Laskarin, M Dominovic… - American journal of …, 2018 - Wiley Online Library
Problem Granulysin (GNLY) is a cytotoxic molecule mostly present in decidual natural killer
(NK) cells. Blighted ovum (BO) and missed abortion (MA) represent the early pathological …

Assessing whether progesterone-matured dendritic cells are responsible for retention of fertilization products in missed abortion

G Laskarin, T Gulic, LG Gacanin, M Dominovic… - Medical hypotheses, 2018 - Elsevier
We hypothesize that progesterone causes tolerogenic maturation of myeloid dendritic cells
(DCs) in human decidua of threatened miscarriage or missed abortion characterized by a …