Novel drug delivery systems for the management of dry eye

N Nagai, H Otake - Advanced drug delivery reviews, 2022 - Elsevier
Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

Nanotechnology for topical drug delivery to the anterior segment of the eye

A Vaneev, V Tikhomirova, N Chesnokova… - International journal of …, 2021 - mdpi.com
Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are
the most prevalent drug form, especially for widely distributed anterior segment eye …

Nano-in-Nano dendrimer gel particles for efficient topical delivery of antiglaucoma drugs into the eye

J Wang, B Li, D Huang, P Norat, M Grannonico… - Chemical Engineering …, 2021 - Elsevier
Low bioavailability of topically applied drugs remains a significant challenge for long-term
glaucoma therapy. To enhance drug delivery efficiency, we developed dendrimer gel …

New nanoparticles for topical ocular delivery of erythropoietin

B Silva, J Marto, B São Braz, E Delgado… - International Journal of …, 2020 - Elsevier
Erythropoietin (EPO) is known for its neuroprotective and neuroregenerative properties. EPO
topical ocular administration has not been tested yet and its bioavailability could be …

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Q Bao, X Zhang, Z Hao, Q Li, F Wu, K Wang, Y Li… - Nano-Micro Letters, 2024 - Springer
The eye, a complex organ isolated from the systemic circulation, presents significant drug
delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier …

Peptide cargo administration: current state and applications

H Rohira, A Arora, P Kaur, A Chugh - Applied Microbiology and …, 2023 - Springer
Effective delivery of drug molecules to the target site is a challenging task. In the last decade,
several innovations in the drug delivery system (DDS) have tremendously improved the …

Erythromycin-loaded polymeric micelles: In situ gel development, in vitro and ex vivo ocular investigations

B Sipos, M Budai-Szűcs, D Kókai, L Orosz… - European Journal of …, 2022 - Elsevier
Our present series of experiments was to create a value-added formulation that has the
potential to exert a powerful and long-lasting antibacterial effect for use in ophthalmology …

Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks

S Ashique, N Mishra, S Mohanto, BHJ Gowda, S Kumar… - Heliyon, 2024 - cell.com
Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and
physiology of the eye. Processed excipients have emerged as crucial components in …

Hydrogels in ophthalmology: Novel strategies for overcoming therapeutic challenges

KY Wu, D Akbar, M Giunta, A Kalevar, SD Tran - Materials, 2023 - mdpi.com
The human eye's intricate anatomical and physiological design necessitates tailored
approaches for managing ocular diseases. Recent advancements in ophthalmology …

Nanomedicine and drug delivery to the retina: Current status and implications for gene therapy

M Tawfik, F Chen, JL Goldberg, BA Sabel - … -schmiedeberg's Archives of …, 2022 - Springer
Blindness affects more than 60 million people worldwide. Retinal disorders, including age-
related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are the …