Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

Serological assessment of cardiac troponins (cTn) is the gold standard to assess myocardial
injury in clinical practice. A greater magnitude of acutely or chronically elevated cTn …

Although aortic stenosis is a common condition associated with major morbidity, mortality,
and health economic costs, there are currently no medical interventions capable of delaying …

Apoptosis is characterised by a series of typical morphological features, such as shrinkage
of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by …

Objectives: The goal of this study was to assess the prognostic significance of midwall and
infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis. Background …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Myocardial infarction is a leading cause of mortality worldwide. Here we report that
modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of …

Background Loss of myocytes is an important mechanism in the development of cardiac
failure of either ischemic or nonischemic origin. However, whether programmed cell death …

resultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well …