Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

This review constitutes a critical evaluation of recent publications that have described an
additional mode of action of the P2Y12 receptor antagonist ticagrelor. The effect is mediated …

Endothelial prostacyclin and nitric oxide potently inhibit platelet functions. Prostacyclin and
nitric oxide actions are mediated by platelet adenylyl and guanylyl cyclases, which …

Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …

Under various pathological conditions, including thrombosis and inflammation, extracellular
nucleotide levels may increase because of both active release and passive leakage from …

Background Ticagrelor is an oral antiplatelet drug that can reversibly bind to the platelet
P2Y12 receptor. Ticagrelor is metabolized mainly by CYP3A4 and produces a rapid blood …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …