The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

Immunomodulatory and allergenic properties of antimicrobial peptides

SV Guryanova, TV Ovchinnikova - International journal of molecular …, 2022 - mdpi.com
With the growing problem of the emergence of antibiotic-resistant bacteria, the search for
alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect …

Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

B He, Z Huang, C Huang… - PROTEOMICS–Clinical …, 2022 - Wiley Online Library
In the context of precision medicine, disease treatment requires individualized strategies
based on the underlying molecular characteristics to overcome therapeutic challenges …

Lung antimicrobial proteins and peptides: From host defense to therapeutic strategies

YP Di, JM Kuhn, ML Mangoni - Physiological Reviews, 2024 - journals.physiology.org
Representing severe morbidity and mortality globally, respiratory infections associated with
chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung …

Peptidomic analyses: The progress in enrichment and identification of endogenous peptides

J Peng, H Zhang, H Niu - TrAC trends in analytical chemistry, 2020 - Elsevier
Peptidomics is the comprehensive profiling of endogenous peptides from the biological
sources. As with genome, transcriptome, proteome and metabolome, the peptidome is …

The potential impact of salivary peptides in periodontitis

C Hirtz, R O'Flynn, PM Voisin… - Critical reviews in …, 2021 - Taylor & Francis
Periodontitis is a complex immune-inflammatory condition characterized by the disruption of
the periodontal ligament and subsequent formation of periodontal pockets, and by alveolar …

Exploiting the human peptidome for novel antimicrobial and anticancer agents

M Bosso, L Ständker, F Kirchhoff, J Münch - Bioorganic & Medicinal …, 2018 - Elsevier
Infectious diseases and cancers are leading causes of death and pose major challenges to
public health. The human peptidome encompasses millions of compounds that display an …

Proteomic and metaproteomic approaches to understand host–microbe interactions

AE Starr, SA Deeke, L Li, X Zhang, R Daoud… - Analytical …, 2018 - ACS Publications
The human body is composed not only of human cells but is occupied by bacteria, archaea,
fungi, and viruses; this ensemble of organisms (microbiota) and their expressed genes are …

Digging deep into peptidomics applied to body fluids

R Vitorino - Proteomics, 2018 - Wiley Online Library
Peptidomics techniques have allowed the identification of thousands of peptides that are
derived from proteins in body fluids, despite the considerable challenges behind sample …

Sequential precipitation and delipidation enables efficient enrichment of low-molecular weight proteins and peptides from human plasma

N Li, Y Zhou, J Wang, L Niu, Q Zhang… - Journal of proteome …, 2020 - ACS Publications
Low-molecular weight proteins and peptides (LMWPs,< 30 kDa) in human plasma serve as
potential biomarkers or drug targets and are endowed with desirable traits for biological and …