Humans and animals live in social relationships shaped by actions of approach and
avoidance. Both are crucial for normal physical and mental development, survival, and well …

This review addresses functional interactions between the primate prefrontal cortex (PFC)
and the amygdala, with emphasis on their contributions to behavior and cognition. The …

Anxious individuals consistently fail in controlling emotional behavior, leading to excessive
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …

Regulating social emotional actions is essential for coping with life stressors and is
associated with control by the anterior prefrontal cortex (aPFC) over the amygdala. However …

Successful responding to acutely threatening situations requires adequate approach–
avoidance decisions. However, it is unclear how threat-induced states—like freezing-related …

Modern research has helped fill in the neural part of Darwin's hypothesis. The brain area
called the amygdala is often said to be the 'fear center'we've inherited from our animal …

Downregulating emotional overreactions toward threats is fundamental for developing
treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for …

Emotion regulation is essential to survive in a world full of challenges with rapidly changing
contextual demands. The ability to flexibly shift between different emotional control …

The ability to respond to emotional events in a context-sensitive and goal-oriented manner is
essential for adaptive functioning. In models of behavioral and emotion regulation, the …

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young
people is critical to understanding their development and improving early intervention and …