Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of
androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key …

Characterization of the molecular pathways that are required for the viability and
maintenance of self-renewing tumor-initiating cells may ultimately lead to improved …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is often
altered in prostate cancer. To determine the prevalence and clinical significance of the …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse
cellular processes including proliferation, adhesion, survival, and motility. Dysregulated …