Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

Intracellular phase separation is emerging as a universal principle for organizing
biochemical reactions in time and space. It remains incompletely resolved how biological …

The last three decades have witnessed an explosion of discoveries about the mechanistic
details of binary fission in model bacteria such as Escherichia coli, Bacillus subtilis, and …

Understanding how to program biological functions into artificial DNA sequences remains a
key challenge in synthetic genomics. Here, we report the chemical synthesis and testing of …

Superresolution fluorescence microscopy and cryogenic electron tomography (CET) are
powerful imaging methods for exploring the subcellular organization of biomolecules …

Selective recruitment and concentration of signalling proteins within membraneless
compartments is a ubiquitous mechanism for subcellular organization,–. The dynamic flow of …

Asymmetric cell division (ACD) produces morphologically and behaviorally distinct cells and
is the primary way to generate cell diversity. In the model bacterium Caulobacter crescentus …

Defining the cellular factors that drive growth rate and proteome composition is essential for
understanding and manipulating cellular systems. In bacteria, ribosome concentration is …

The Gram-positive bacterium Bacillus subtilis can divide via two modes. During vegetative
growth, the division septum is formed at the midcell to produce two equal daughter cells …

Supported by the tools of contemporary synthetic biology, the field of metabolic engineering
has advanced in its overarching purpose of contributing efficient bioprocesses for the …